As I had been to the Czech Republic a few times before I didn't put much research in to this visit. I revisited my trusty mini Berlitz guide to Prague and did a few web-searches mainly to choose a hotel and to see if there were any hidden gems I could introduce my sister to.
We both flew from Stansted to Brno, which cost £72.06 each with hand-baggage only. I flew back separately from Prague to London Gatwick and used my Nectar points to reduce my fare from £33.59 to £3.09 :)
The site for The State Castle of Vranov nad Dyji http://www.zamekvranov.cz/
We travelled from Brno to Prague on a 'Student Agency' bus. These can be booked online, if you follow this link and select Online Ticket Reservation on the right for that journey you can check the price and book. http://www.studentagency.eu/
Once in Prague, the metro is very easy to navigate, with only three lines which intersect at Florenc, Muzeum and Mustek. http://www.pragueexperience.com/maps/metro.asp I found this site useful for explaining the ticketing system: http://www.prague.net/public-transport-tickets
We stayed at the Hotel Assenzio http://www.hotelassenzioprague.com/ which was only a couple of metro stops out of the centre and of a decent enough standard. Unfortunately it stands between two main roads, but I didn't find that a problem as I was lights-out after a day of walking and sight-seeing. I used a cashback site (http://www.topcashback.co.uk/ref/bangarara) to book via Hotels.com and got 10% back.
No trip to Prague is complete without visiting the castle http://www.hrad.cz/en/prague-castle/prague-castle-tourist-information/visit-of-prague-castle.shtml
I usually like to join a free tour if I can find one, but didn't have time on this visit. This is the one that I would have joined! http://www.newpraguetours.com/
This site was handy for checking out things to visit, and to avoid. http://www.uncorneredmarket.com/2011/05/prague-tourist-traps-sites-restaurants/